This memorial website was created in the memory of our bravest little sister, Celeste Martinez. We will remember our little Princess forever.
Celeste was born on October 10, 2001 at Herman Hospital in Houston Texas to Sarah Motilla. She grew her wings on March 4, 2005. She may have been with us 3 short years, but she touched the lives of many. Everyone who seen her completely fell in love with her, even though she spent most of the time in the hospital. She was a very happy baby and she brought great happiness to others as well. Celeste is in fact the bravest one ever. She was a superwoman when it came to shots, medication and pain! Celeste has 2 sisters and 1 brother. Melissa Motilla, George Motilla and Sarah Motilla. She never had a chance to meet her older brother but we told her all the time about him while he was away.
We will miss our little princess, she will forever stay in our hearts.
We will see you in GODS world sweetie!
Love you lots.
Dr. Mc. Clain
Langerhans cell histiocytosis (LCH) is one of the rare diseases seen by pediatric oncologists that in the past was treated by several different methods – from surgery alone to radiation therapy and several types of chemotherapy.
Many investigators are unaware of the organized clinical trials sponsored by the Histiocyte Society (HS). The trials have provided important data on efficacy of the best medications available, but more importantly have taught us about the long-term consequences of LCH, especially regarding central nervous system disease associated with skull lesions of the orbit, mastoid and temporal bone. These lesions must be treated with velban and prednisone for at least six months to reduce the risk of developing diabetes insipidus from 40 percent to 20 percent. The next treatment study will have to address how to further reduce this risk.
Another recent discovery is that pulmonary disease in children may not be a high-risk organ as has classically been taught. For years, LCH of the liver, spleen, bone, marrow and lung has been classified as needing more vigorous treatment than that of bone, skin or lymph node. Published evidence now exists that shows children with pulmonary disease – with or without the low-risk sites – have better chances of cure than those with other high-risk organs.
Recently, a nearly 2-year-old patient with pulmonary, liver and spleen LCH had a remarkable response in her lungs to a new chemotherapy plan. The patient had not responded well to initial treatment with vinblastine, prednisone and methotrexate at another hospital during the first months of 2005. I consulted with the patient’s physicians and recommended treatment with 2-CdA (Cladribine) and cytosine arabinoside. After two courses, the patient improved, but her lungs were so badly affected that a lung transplant became necessary.
The patient transferred to Texas Children’s Hospital, and my colleagues and I were astonished at how little functional lung remained (less than 20 percent) and the fact that the child played actively and had an oxygen saturation of over 90 percent on room air. Since her liver was still enlarged, she was treated with another course of 2-CdA alone at a reduced dose while awaiting the decision about a lung transplant. One month after that therapy, a CT of her lungs showed an amazing amount of good lung tissue – more than 40 percent. This could have resulted from resolution of nodules causing blockage of bronchi and cysts such that functional lung became aerated again. It also is possible that this young child could have redeveloped functional lung tissue. Given the good response, it was decided to give the child some more time to grow and decide later if a lung transplant is needed.
Texas Children’s Cancer Center’s Histiocytosis Center has been participating in the Histiocyte Society trials for more than 10 years and is a leading contributor of patients to these trials, as well as a referral center for patients from all over South and North America seeking help with the diagnosis and treatment of the histiocytic disorders including LCH, Hemophagocytic Lymphohistiocytosis (HLH), Rosai-Dorfman disease (Sinus Histiocytosis with Massive Lymphadenopathy), juvenile xanthogranuloma, Erdheim-Chester Disease and others.
It is only through cooperative trials that progress will be made in understanding the cause and cure of these rare diseases. We welcome your questions and look forward to collaborating with you.
About the author
Kenneth McClain, M.D., Ph.D., is the clinical director of Texas Children’s Cancer Center’s Histiocytosis Center and professor of pediatrics of Baylor College of Medicine. Dr. McClain and his staff see more than 40 new patients annually in Texas Children’s Cancer Center’s Histiocytosis Center. A leader in promoting trials of new drugs – such as thalidomide for low-risk LCH and use of vincristine and cytosine arabinoside for central nervous system LCH – the goal of the center is to provide the latest therapeutic options for patients while supporting the efforts of physicians worldwide in placing patients in the Histiocyte Society’s clinical trials.
McClain KL, Drug Therapy for Treatment of Langerhans Cell Histiocytosis. Expert Opinion on Pharmacotherapy.2005;6:2435-2441. PMID: 16259575
After that being said: The doctor told us she was not going to see 3 yeasrs old. However she made 3 1/2 years.
I would love to express my feelings as me being Celestes older sister to thank the staff at Texas Childrens Hospital and her nurse that was there by her side Mrs. Diana. My sister Sarah for placing her life on hold while I continued to worked. My grandma Margaret Motilla for always showing grandma love and always had her arms open for us when we needed to be loved. My mom now for being strong and here for us now. I know my mom was not there when we had to go through Celestes sickness 100% but she deals with it now. Just as long as you turn to GOD you can overcome anything. He will forgive.
My heart will always be touched by you.
Sweet Baby girl in heaven above,
God sent you to us with much love,
Not knowing what pain it would cause.
I deal with it just because.
The few moments I had you in my arms,
Will last me til the end of time,
Til I see and know you were really mine.
All my love I send to you,
In hopes you wont be blue.
Oh my sweet angel,
Look down on me,
Take this pain and set me free.
I long to see you in the future,
To hold you and kiss you,
And show you I really missed you